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The SACGM Compendium of guidance

Guidance from the Scientific Advisory Committee on Genetic Modification

Since 1 October 2014, parts 1 and 3 of the guidance do not reflect the current Genetically Modified Organisms (Contained Use) Regulations 2014. Specific references to the legislation, operation of the safety committee and containment requirements in these parts need to be updated. Although legally correct, the opportunity will also be taken to amend the other parts of the guidance (parts 2, 4, 5 and 6) to take account of current working practices and technological advances.

This is guidance prepared, in consultation with HSE, by the SAGCM which was appointed by the Health and Safety Commission as part of its formal advisory structure. The guidance represents what is considered to be good practice by the members of the Committee. It has been agreed by the Commission. Following this guidance is not compulsory and you are free to take other action. But if you do follow this guidance you will normally be doing enough to comply with the law. Health and safety inspectors seek to secure compliance with the law and may refer to this guidance as illustrating good practice.

This document is available as a series of PDF files (viewable with Acrobat Reader) linked below.

Link URLs in this page

  1. Biosafetyhttps://www.hse.gov.uk/biosafety/index.htm
  2. Safety noticeshttps://www.hse.gov.uk/biosafety/notices/index.htm
  3. Overview - The regulation of specified animal pathogenshttps://www.hse.gov.uk/biosafety/sapo.htm
  4. Background on the regulation of specified animal pathogenshttps://www.hse.gov.uk/biosafety/background.htm
  5. SAPO Application processhttps://www.hse.gov.uk/biosafety/app-process.htm
  6. How do I make my application?https://www.hse.gov.uk/biosafety/how-do-i.htm
  7. Notifying accidents and dangerous occurrencehttps://www.hse.gov.uk/biosafety/notify.htm
  8. Guidance on Appeals for Notices issued under SAPOhttps://www.hse.gov.uk/biosafety/guidance-appeals-sapo.htm
  9. Overview - Infections at workhttps://www.hse.gov.uk/biosafety/infection.htm
  10. Preventing infections at workhttps://www.hse.gov.uk/biosafety/about.htm
  11. HSE and infectionshttps://www.hse.gov.uk/biosafety/hseandinfection.htm
  12. Overview - Are you at risk?https://www.hse.gov.uk/biosafety/microorganisms.htm
  13. Laboratory workhttps://www.hse.gov.uk/biosafety/laboratories.htm
  14. Healthcarehttps://www.hse.gov.uk/biosafety/healthcare.htm
  15. Overview - Specific infectionshttps://www.hse.gov.uk/biosafety/diseases/index.htm
  16. Overview - Influenzahttps://www.hse.gov.uk/biosafety/diseases/influenza.htm
  17. Avian influenzahttps://www.hse.gov.uk/biosafety/diseases/avianflu.htm
  18. Pandemic influenzahttps://www.hse.gov.uk/biosafety/diseases/pandemic.htm
  19. Workplace guidancehttps://www.hse.gov.uk/biosafety/diseases/pandflu.htm
  20. Anthraxhttps://www.hse.gov.uk/biosafety/diseases/anthrax.htm
  21. Zoonoseshttps://www.hse.gov.uk/biosafety/diseases/zoonoses.htm
  22. Bovine spongiform encephalopathy (BSE)https://www.hse.gov.uk/biosafety/diseases/bovine.htm
  23. Handling the deceased with suspected or confirmed COVIDhttps://www.hse.gov.uk/biosafety/handling-the-deceased.htm
  24. What the Law says about Biosafetyhttps://www.hse.gov.uk/biosafety/law.htm
  25. Biosafety Resourceshttps://www.hse.gov.uk/biosafety/information.htm
  26. Useful linkshttps://www.hse.gov.uk/biosafety/links.htm
  27. Blood-borne viruseshttps://www.hse.gov.uk/biosafety/blood-borne-viruses/index.htm
  28. Overview - GMOhttps://www.hse.gov.uk/biosafety/gmo/index.htm
  29. What are GMOs?https://www.hse.gov.uk/biosafety/gmo/whatare.htm
  30. Who is responsible for GMO (CU) Regulations?https://www.hse.gov.uk/biosafety/gmo/whos-responsible.htm
  31. GMOs and the lawhttps://www.hse.gov.uk/biosafety/gmo/law.htm
  32. GMO Notificationshttps://www.hse.gov.uk/biosafety/gmo/notifications/index.htm
  33. What do I notify?https://www.hse.gov.uk/biosafety/gmo/notifications/what.htm
  34. How do I notify?https://www.hse.gov.uk/biosafety/gmo/notifications/process.htm
  35. Feeshttps://www.hse.gov.uk/biosafety/gmo/notifications/fees.htm
  36. Appealshttps://www.hse.gov.uk/biosafety/gmo/notifications/appeals.htm
  37. Confidentiality and disclosure of notified datahttps://www.hse.gov.uk/biosafety/gmo/notifications/confid.htm
  38. Description of the Public Registerhttps://www.hse.gov.uk/biosafety/gmo/notifications/publicregister.htm
  39. Overview - Resourceshttps://www.hse.gov.uk/biosafety/gmo/information.htm
  40. The SACGM Compendium of Guidancehttps://www.hse.gov.uk/biosafety/gmo/acgm/acgmcomp/index.htm
  41. Risk assessment guidancehttps://www.hse.gov.uk/biosafety/gmo/acgm/index.htm
  42. Part 1: Introduction to the legislation and general health and safety issueshttps://www.hse.gov.uk/biosafety/assets/docs/part1.pdf
  43. Part 2: Risk assessment of genetically modified microorganisms (other than those associated with plants)https://www.hse.gov.uk/biosafety/assets/docs/part2.pdf
  44. Part 3: Containment and control of activities involving genetically modified microorganisms https://www.hse.gov.uk/biosafety/assets/docs/part3.pdf
  45. Part 4: Genetic modification work that involves plants (including plant-associated genetically modified microorganisms)https://www.hse.gov.uk/biosafety/assets/docs/part4.pdf
  46. Part 5: Genetic modification of animalshttps://www.hse.gov.uk/biosafety/assets/docs/part5.pdf
  47. Part 6: Guidance on the use of genetically modified microorganisms in a clinical setting https://www.hse.gov.uk/biosafety/assets/docs/part6.pdf
  48. List of abbreviationshttps://www.hse.gov.uk/biosafety/assets/docs/abbreviations.pdf
  49. The Genetically Modified Organisms (Contained Use) Regulations 2014https://www.hse.gov.uk/pubns/books/l29.htm
  50. Department for Environment, Food and Rural Affairs https://www.gov.uk/government/organisations/department-for-environment-food-rural-affairs
  51. Department of Health https://www.gov.uk/government/organisations/department-of-health
  52. Food Standards Agencyhttp://www.food.gov.uk/
  53. COSHHhttps://www.hse.gov.uk/coshh/index.htm
  54. RIDDORhttps://www.hse.gov.uk/riddor/index.htm
  55. Skinhttps://www.hse.gov.uk/skin/index.htm
  56. Health and social carehttps://www.hse.gov.uk/healthservices/index.htm

Glossary of abbreviations/acronyms on this page

GMO
Genetically modified organisms

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Updated 2023-06-02